Photocatalytic Indole Ring ‘Editing’ to Quinazoline for Tryptophan Site-Specific Peptide Modification

Photocatalytic Indole Ring 'Editing' to Quinazoline for Tryptophan Site-Specific Peptide Modification

Image source: J. Am. Chem. Soc.Introduction:Site-specific late-stage modification of natural peptide chains is an ideal strategy for developing bioactive peptide analogs in an efficient and economical manner. The emerging concept of scaffold editing provides new ideas for developing next-generation methods for late-stage peptide modifications. This study developed a simple tryptophan-specific late-stage modification method for peptide … Read more

Modular Synthesis of C2-Substituted Bicyclo[1.1.1]pentanes via Photocatalysis

Modular Synthesis of C2-Substituted Bicyclo[1.1.1]pentanes via Photocatalysis

Image SourceJ. Am. Chem. Soc. Abstract:Bicyclo[1.1.1]pentanes (BCPs) play a crucial role as saturated bioisosteres for planar phenyl rings. As strategic three-dimensional substitutes for ortho- or meta-substituted aromatics, C2-substituted BCPs provide an opportunity to access an underexplored chemical space. Finding efficient and broadly applicable synthetic routes for these scaffolds remains a significant challenge, primarily due to … Read more