bioisosteres

Image SourceJ. Am. Chem. Soc. Abstract:Bicyclo[1.1.1]pentanes (BCPs) play a crucial role as saturated bioisosteres for planar phenyl rings. As strategic three-dimensional substitutes for ortho- or meta-substituted aromatics, C2-substituted BCPs provide an opportunity to access an underexplored chemical space. Finding efficient and broadly applicable synthetic routes for these scaffolds remains a significant challenge, primarily due to … Read more