Multikilogram-Scale Synthesis of a Chiral Cyclopropanol
Org. Process Res.Dev. 2012, 16, 87–95. DOI: 10.1021/op2002497 ◆Initial attempts to perform a diastereoselective cyclopropanation of a tartaramide-modified vinyl boronate 6 gave a 24% yield of 2 after oxidative cleavage, with significant process impurities which could only be removed after a difficult chromatography. ◆Treatment of commercially available pinacolvinyl boronate 4 with bis-iodomethylzinc (Zn(CH2I)2) prepared from … Read more