Literature Sharing | J. Am. Chem. Soc | Enzyme-Activated Sugar-Coated Bifunctional Degraders
The team of Christina M. Woo from Harvard University’s Department of Chemistry and Chemical Biology has developed an enzyme activation strategy by integrating O-GlcNAc modifications into the ligands of cyclimids recognized by cereblon (CRBN). These sugar-coated PROTACs (SCPs) were designed based on structural analysis of representative cyclimids that degrade CRBN and the target protein BRD4. … Read more