Chapter 1: Chronic Myeloid Leukemia
Definition:Chronic Myeloid Leukemia (CML) is caused by the chromosomal translocation (9;22)(q34.1;q11.2), which leads to the formation of the Philadelphia (Ph) chromosome containing the BCR::ABL1 fusion gene. The BCR::ABL1 oncogenic protein acts as a constitutively activated tyrosine kinase, driving malignant transformation by activating multiple signaling pathways. Granulocytes are the main proliferative component, but all myeloid lineages … Read more