Single Quinoline Modification of Vancomycin: An Effective Strategy to Alter Antibacterial Spectrum and Combat Multidrug Resistance

Single Quinoline Modification of Vancomycin: An Effective Strategy to Alter Antibacterial Spectrum and Combat Multidrug Resistance

On November 10, 2025, the research team led by Guan Dongliang from the Shandong Provincial Laboratory of New Drug Creation in Yantai, in collaboration with the research group of Zhang Jinyong from the National Engineering Research Center for Immunological Products at the Army Medical University, published a study titled “Unanticipated Quinoline Modification on Vancomycin as … Read more

Chemotype- and Target-Driven Genome Mining for a New Natural Product Inhibitor of Bacterial Peptide Deformylase

Chemotype- and Target-Driven Genome Mining for a New Natural Product Inhibitor of Bacterial Peptide Deformylase

ClickBlueWords to Follow Us Hello everyone, the article we are sharing today is titled “Chemotype- and Target-Driven Genome Mining for a New Natural Product Inhibitor of Bacterial Peptide Deformylase,” published in June 2025 in the Journal of the American Chemical Society. The use of antibiotics drives the evolution of antimicrobial resistance (AMR), which limits the … Read more

Diagnosis and Management of Five Common Infection Syndromes in the ICU

Diagnosis and Management of Five Common Infection Syndromes in the ICU

Antimicrobial resistance (AMR) is an urgent threat to global health, accelerated by the inappropriate use of antibiotics. Antimicrobial stewardship (AMS) is crucial for optimizing patient outcomes, minimizing drug toxicity, and the emergence of resistance. Diagnostic stewardship (DS) is an important component of AMS, requiring the right tests to be ordered for the right patients at … Read more