On August 6, Science Advances published a study by the team of Wei Gao from the California Institute of Technology regarding a sweat sensor research achievement. This work introduces a Stressomic, a wearable microfluidic biosensor designed for non-invasive monitoring of cortisol, adrenaline, and norepinephrine in sweat, which is significant for personalized stress management and a deeper understanding of the biological mechanisms of stress. (Sci.Adv: The black technology that makes your stress visible! Based on a wearable microfluidic biosensor – dynamic analysis of multiple stress hormone levels in sweat)
A week later, the Wei Gao team’s another research achievement on sweat sensors was successfully published in Science Advances. This work introduces a BMS3, a biomimetic microfluidic wearable sweat sensor system designed for multi-day continuous metabolic monitoring.BMS3 combines hierarchical microchannels and superhydrophobic – superhydrophilic Janus membrane structures, inspired by the hairs of the sundew and the leaves of the lotus, enabling efficient collection, transport, and renewal of small amounts of sweat. A micro-sized choline gel-based ion dialysis module can autonomously induce local sweat secretion.
Additionally, the microfluidic design can continuously collect sweat for over 2 days after a single ion dialysis operation without requiring physical activity. In vitro and in vivo studies in healthy participants and gout patients have demonstrated the capability of BMS3 for continuous metabolic monitoring. By simultaneously monitoring levels of uric acid, xanthine, and alcohol, it can effectively distinguish between normal and pathological states and provide timely therapeutic feedback.
Figure1 BMS3 – A biomimetic microfluidic sweat sensor system
Figure 2 Design and characteristic analysis of the multi-channel sensor patch
Figure 3 Design and characteristic study of biomimetic microfluidic technology for low-volume sweat collection and transport
Figure4 BMS3 In vivo evaluation in healthy subjects and gout patients
- Original title: A bioinspired microfluidic wearable sensor for multiday sweat sampling, transport, and metabolic analysis
- Co-first authors of the paper: Soyoung Shin, Ruixiao Liu, Yiran Yang
- Original link: https://www.science.org/doi/10.1126/sciadv.adw9024
Disclaimer: If there are inaccuracies or issues related to intellectual property, please feel free to message for corrections/deletions.
