Minimally Invasive Tumor Techniques Series – 3D Printed Coplanar Template-Assisted Radioactive Particle Implantation 2026-02-16 Minimally Invasive Tumor Techniques Series – 3D Printed Coplanar Template-Assisted Radioactive Particle Implantation On April 22, 2025, Dr. Liu Enyue from the Oncology Department of Rizhao Traditional Chinese Medicine Hospital performed the first 3D printed coplanar template-assisted radioactive particle implantation in the hospital, marking his first surgery after returning from training at Beijing Medical University. Here, we introduce the diagnostic and treatment guidelines for radioactive particle implantation and expert consensus. 1. Indications (1) Aged 18-80, KPS ≥ 70 (2) Pathologically confirmed malignant tumors (3) Not suitable for or refuse surgery, recurrence after surgery or external radiotherapy (4) Tumor diameter ≤ 7 cm, no distant metastasis or limited metastasis (≤ 5 metastatic lesions) with stable metastasis after active treatment (5) Suitable puncture path with expected prescribed dose achievable. 2. Contraindications (1) Poor general condition, expected survival < 3 months (2) Severe comorbidities, infection, immunocompromised state, and organ dysfunction (3) Platelets < 75×10^9/L and severe coagulation disorders (prothrombin time > 18s, prothrombin activity < 40%); (4) Lesions adjacent to or encasing trachea, blood vessels, or lesions with cavities or liquefactive necrosis. 3. Relative contraindications (1) Age < 18 or > 80 (2) Tumor diameter > 7 cm (3) Allergy to iodine contrast agents, unable to perform enhanced scanning for planning or efficacy evaluation. Case Study: Patient Li, female, 54 years old, diagnosed with right lung adenocarcinoma with multiple bone metastases. After multiple lines of targeted therapy, chemotherapy, and radiotherapy, her condition continued to progress, particularly with significant pain from the right rib metastatic tumor, severely affecting her quality of life, requiring a maximum oral dose of 1200 mg of oxycodone hydrochloride sustained-release tablets every 12 hours. Preoperative Enhanced Localization Preoperative Physical Planning Determines Prescribed Dose, Number of Particles, Particle Distribution, and Dose Coverage Preoperative Physical Planning – Dose-Volume Histogram Disinfection of the Surgical Area 3D Printed Flat Template Particle Needle Insertion Process Process of Implanting Radioactive Particles into the Tumor via Particle Needle Intraoperative Particle Precise Puncture into the Tumor According to Preoperative Physical Plan Intraoperative Precise Implantation of Radioactive Particles into the Tumor, Consistent with Preoperative Plan in Terms of Particle Distribution, Spacing, and Quantity Postoperative Follow-up at 2 Months and Dose Verification, Significant Reduction in Tumor Volume, and Notable Relief of Pain, Maximum Oral Dose of Oxycodone Hydrochloride Sustained-Release Tablets 500 mg every 12 hours. Related posts Restoring Movement in Paralyzed Mice! Bioprinting Brings Hope to Life | New Forces in Entrepreneurship Comprehensive Analysis of IoT Technology: Understand Core Technologies from Hardware to Cloud Platform!