The dynamic characteristics of non-covalent bonds in peptide self-assembly can selectively accommodate guest molecules. However, how to utilize co-assembly to enhance the application defects of host peptides while improving guest molecules remains unclear. In this regard, Professors Wang Weizhi and Niu Guangle from Beijing Institute of Technology aim to realize the supramolecular synergy between the host and guest to further expand the functional space of hybrid nanostructures.
Key Points of the Article:
(1)The experiment utilizes the aromatic region present in β-sheet peptides to accommodate aromatic molecules, thereby forming nanotubes (NQ40@AIF) through a unique “cross-strand π−π interlocking”. The study finds that this strategy not only effectively stabilizes co-assembly but also achieves biological functional synergy between host and guest molecules.
(2)Experimental results indicate that due to the chemical diversity of the co-assembled NQ40@AIF, it has significant advantages in tumor combination therapy, achieving effective synergy of ferroptosis and immune checkpoint blocking. In summary, this research provides a simple new strategy for constructing peptide nanostructures with complex functions.
References:
Limin Zhang et al. Harnessing Cross-strand π−π Interlocking for Synergistic Enhancement of Immune Checkpoint Blocking and Ferroptosis. Nano Letters. 2024
DOI: 10.1021/acs.nanolett.4c04625
https://pubs.acs.org/doi/10.1021/acs.nanolett.4c04625
