Bidirectional Regulation of Neural Plasticity Using Self-Powered Devices

Recently, the Brain Intelligence Center team led by Zhan Yang at the Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, in collaboration with the Neural Engineering Center team led by Li Guanglin and the team led by Xue Xinyu from the University of Electronic Science and Technology, developed a self-powered flexible wearable neural stimulator that achieves bidirectional regulation of neural plasticity. The related findings were published in Nano Energy (impact factor 16.602) under the title Bidirectional modulation of neural plasticity by self-powered neural stimulation. This work provides new ideas for the treatment of neurological diseases based on synaptic plasticity and bidirectional brain-machine interaction.

Regulating neural plasticity is considered an effective means to treat diseases such as Alzheimer’s disease, drug addiction, and stroke. Currently, common commercial neural stimulators typically require batteries or power outlets to meet power demands, and the bulky system frameworks and inflexible component designs limit the flexible application of the devices. To overcome this technical bottleneck, the research team collaborated to design a self-powered flexible wearable neural stimulator that induces long-term potentiation or long-term depression through the generation of high-frequency and low-frequency pulse modes, achieving bidirectional regulation of neural plasticity. This self-powered flexible wearable neural stimulator integrates a flexible self-powered nano-generator, signal modulation module, and neural stimulation electrodes, offering advantages such as small size, light weight, and portability, capable of converting mechanical energy generated during movement into neural stimulation signals to regulate synaptic plasticity.
Bidirectional Regulation of Neural Plasticity Using Self-Powered Devices
Bidirectional Regulation of Neural Plasticity by Self-Powered Neural Stimulator
The self-powered flexible wearable neural stimulator was validated in awake animal models. Researchers connected the device to the brains of mice, where the signal modulation module converted the collected energy into dual-mode stimulation signals, successfully inducing long-term potentiation and long-term depression in the hippocampus without external power supply. This work overcomes the drawbacks of traditional commercial electrical stimulation devices, such as bulkiness and potential hazards associated with supporting power supplies, providing new ideas for the treatment of neurological diseases based on synaptic plasticity and bidirectional brain-machine interaction.
This project was funded by the National Key Research and Development Program, the National Natural Science Foundation, the Shenzhen-Hong Kong Brain Science Research Institute, and the Sichuan Science and Technology Program.
Source: Brain Institute
Editor: Tian Jing
Editor-in-Chief: Feng Chun
Bidirectional Regulation of Neural Plasticity Using Self-Powered Devices
Bidirectional Regulation of Neural Plasticity Using Self-Powered Devices
Bidirectional Regulation of Neural Plasticity Using Self-Powered Devices
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