The αC-β4 Loop Structure of HER2 in Lung Cancer: Decoding the Key to Overcoming Resistance in Targeted Therapy
Abstract National Natural Science Foundation Project Report HER2 exon 20 insertion mutations (HER2 20ins) are the most common type of HER2 mutations in lung cancer, accounting for 62%-90%. However, the response rate of these patients to existing targeted drugs (such as TKIs) is only 10%-30%, and the mechanisms of resistance have long been unclear. The … Read more