Essential Tests for Endometrial Cancer – POLE Gene Testing
Overview The POLE gene belongs to the DNA polymerase B family and is a catalytic subunit of DNA polymerase ε, possessing 5’→3’ DNA polymerase activity and 3’→5’ exonuclease activity, which play a crucial role in DNA replication and proofreading. Mutations in the exonuclease domain of this gene, which includes exons 9 to 14, can lead … Read more