Dual Evolutionary Pathways of Genomic Structural Diversity in High-Grade Serous Ovarian Cancer (HGSOC) and Their Impact on Patient Prognosis
Recent studies reveal a “dual evolutionary” pattern in pancreatic cancer similar to that of ovarian cancer: the HRD pathway is primarily characterized by DNA deletions, while the WGD pathway drives tumor malignancy through chromosomal fragmentation and ecDNA amplification. Key findings include that mitochondrial mutations significantly affect prognosis (with a hazard ratio of 3.1), and CDK12 … Read more