First Direct Trifluoromethoxylation of Aryl Halides Achieved by the Team of Professor Tang Pingping at Nankai University
The trifluoromethoxy group (-OCF3) is a highly valuable functional group in the design of pharmaceutical and pesticide molecules—its unique stereostructure (perpendicular to the aromatic ring plane) can significantly enhance the binding ability of molecules to biological targets. Additionally, its strong electron-withdrawing nature and high lipophilicity can improve the metabolic stability and cell membrane permeability of … Read more