Determination of Polysaccharide Content and Molecular Size Distribution of A, C, Y, and W135 Group Meningococcal Polysaccharide Vaccine by Capillary Zone Electrophoresis
Abstract Objective To establish a capillary zone electrophoresis method to detect the polysaccharide content and molecular size distribution of A, C, Y, and W135 group meningococcal polysaccharide vaccines. Methods A capillary zone electrophoresis method was established to detect four types of polysaccharides, exploring the optimal separation voltage and temperature. The method characterizes the four polysaccharides … Read more