Tantalum (Ta), with a high X-ray attenuation coefficient and good biocompatibility, is an important element for constructing computed tomography (CT) imaging probes. However, how to construct Ta-based imaging probes that can be cleared by the kidneys through a simple method remains a significant challenge.
In light of this, Professor Sun Shaokai from Tianjin Medical University designed a simple method to synthesize gram-scale, kidney-clearable, high water-soluble Ta nanodots for in vivo CT imaging.
Key Points of this Article:
(1) The experiment prepared Ta nanodot coordination polymers through the coordination reaction of Ta(OH)5, citric acid (CA), and hydrogen peroxide, which possess an ultra-small hydrodynamic diameter (2.8 nm), high water solubility (1.88 g/mL, 688 mg Ta/mL), superior X-ray absorption capability, the ability to achieve gram-scale preparation (laboratory synthesis >10 g), renal clearance capability, and good biocompatibility.
(2) The study found that the Ta nanodots exhibited excellent CT imaging performance at different tube voltages, enabling high sensitivity gastrointestinal CT imaging, renal CT imaging, and CT angiography (CTA). Experimental results showed that even under high-energy X-rays, Ta nanodots maintained strong CT imaging performance, and spectral CT based on Ta nanodots can achieve minimized metal artifacts in CTA.
In summary, the Ta nanodots constructed in this study are an effective CT imaging probe for diagnosing various diseases.
References:
Yanzhi Dong. et al. Gram-Scale Synthesis of Renal-Clearable Tantalum Nanodots with High Water Solubility for Computed Tomography Imaging In Vivo. ACS Nano. 2024
DOI: 10.1021/acsnano.4c06705
https://pubs.acs.org/doi/10.1021/acsnano.4c06705
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