PTEN Self-Regulation via PI3K-FOXO Pathway and USP11 Stabilization
PTEN is a lipid phosphatase that antagonizes the PI3K/AKT pathway and is considered a major dose-dependent tumor suppressor. Therefore, the cellular mechanisms controlling PTEN levels provide potential therapeutic avenues, but these pathways have not been clearly defined. Here, the authors demonstrate that PTEN transcriptionally upregulates the deubiquitinating enzyme USP11 via the PI3K/FOXO pathway, playing an … Read more